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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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SLC66A2
solute carrier family 66 member 2
Chromosome 18 Β· 18q23
NCBI Gene: 80148Ensembl: ENSG00000122490.19HGNC: HGNC:26188UniProt: K7ERV4
8PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingretrograde transport, endosome to Golgiphospholipid translocationendosome membraneschizophreniasign or symptomliver diseaseAbruptio Placentae
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

solute carrier family 66 member 2

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
schizophreniaOpen Targets
0.35Weak
sign or symptomOpen Targets
0.35Weak
liver diseaseOpen Targets
0.28Weak
Abruptio PlacentaeOpen Targets
0.25Weak
asthmaOpen Targets
0.08Suggestive
gastroesophageal reflux diseaseOpen Targets
0.04Suggestive
mathematical abilityOpen Targets
0.02Suggestive
response to isoquinoline alkaloidOpen Targets
0.02Suggestive
acute myeloid leukemiaOpen Targets
0.01Suggestive
myopiaOpen Targets
0.01Suggestive
acute lymphoblastic leukemiaOpen Targets
0.01Suggestive
cancerOpen Targets
0.01Suggestive
chronic kidney diseaseOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
chronic myelogenous leukemiaOpen Targets
0.00Suggestive
HyperoxaluriaOpen Targets
0.00Suggestive
squamous cell carcinomaOpen Targets
0.00Suggestive
cervical cancerOpen Targets
0.00Suggestive
esophageal cancerOpen Targets
0.00Suggestive
Hereditary breast cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
DENND2AShared pathway50%TMEM87BShared pathway50%DENND5AShared pathway33%BET1LShared pathway33%TBC1D10CShared pathway33%TBC1D17Shared pathway33%
Tissue Expression6 tissues
Liver
100%
Lung
26%
Bone Marrow
24%
Ovary
14%
Heart
12%
Brain
11%
Gene Interaction Network
Click a node to explore
SLC66A2DENND2ATMEM87BDENND5ABET1LTBC1D10CTBC1D17
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q8N2U9
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.26LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.91 [0.67–1.26]
RankingsWhere SLC66A2 stands among ~20K protein-coding genes
  • #17,711of 20,598
    Most Researched8
  • #13,311of 17,882
    Most Constrained (LOEUF)1.26
Genes detectedSLC66A2
Sources retrieved0 papers
Response timeβ€”