SLCO3A1 encodes a solute carrier organic anion transporter mediating transport of steroid hormone precursors including dehydroepiandrosterone 3-sulfate and estrone 3-sulfate 1. The protein also functions as a bile acid efflux transporter that is upregulated during cholestasis as an adaptive response 1. Additionally, SLCO3A1 transports prostaglandin E2 and thyroxine 1. Mechanism: SLCO3A1 regulates inflammatory signaling through NF-κB transcription factor activation 2. In hepatocytes, fibroblast growth factor 19 signaling activates Sp1 and NF-κB transcription factors to upregulate SLCO3A1 expression 1. Disease relevance: SLCO3A1 variants associate with Crohn's disease; the rs207959 T allele increases risk for intestinal perforation through elevated NF-κB activity 2. Genetic variation also associates with nicotine dependence 3, medication-induced QT prolongation 4, varenicline-induced nausea 5, and functional outcomes after ischemic stroke 6. Clinical significance: SLCO3A1 expression is substantially elevated in human skin relative to other transporters 7, and the gene is expressed in respiratory epithelium 8. These findings suggest SLCO3A1 may influence drug efficacy and adverse effects across multiple therapeutic contexts.