SNRK (SNF-related kinase) is a serine/threonine protein kinase belonging to the AMPK-related superfamily 1 that functions as a metabolic regulator with pleiotropic roles in cellular homeostasis. Structurally, SNRK contains a serine/threonine kinase catalytic domain, nuclear targeting signals, and an ubiquitin-associated domain 2. The kinase is highly expressed in hematopoietic progenitors during development, suggesting roles in hematopoietic cell proliferation and differentiation 2. In endothelial cells, SNRK promotes angiogenesis through HIF1α-dependent upregulation and subsequent SNRK/SP1-mediated ITGB1 expression, enhancing EC migration and neovessel formation 1. SNRK regulates lipid metabolism by binding mTOR complex 1 raptor, promoting hepatic fatty acid oxidation and autophagy to maintain liver lipid homeostasis in metabolic-associated fatty liver disease 3. In cardiac tissue, high atrial SNRK expression suppresses TGFβ1 secretion from cardiomyocytes, preventing fibroblast activation and atrial fibrosis 4. During acute kidney injury, the miR-223-3p/HDAC2/SNRK axis mediates BMSC-derived extracellular vesicle-induced reduction of inflammation and pyroptosis 5. SNRK expression is reduced in Kawasaki disease and vasculitis, serving as a potential diagnostic biomarker and therapeutic target 6. Anti-SNRK antibodies predict favorable response to JAK inhibitor therapy in rheumatoid arthritis 7, while SNRK itself functions as an anti-inflammatory mediator 8.