SNTG1 encodes γ-1 syntrophin, a neuronal-specific adapter protein that is part of the dystrophin-associated protein complex 1. The protein functions as a cytoplasmic peripheral membrane protein that associates directly with dystrophin and likely organizes subcellular localization of various proteins by linking receptors to the actin cytoskeleton 1. SNTG1 expression is restricted to neurons, particularly in brain areas involved in postural control 2. The gene has significant clinical relevance in skeletal disorders, with disruptions associated with idiopathic scoliosis through chr8 rearrangements that break between exons 10 and 11 12. Rare variants near SNTG1 are associated with bone mineral density in Asian populations, with preliminary evidence suggesting these variants upregulate SNTG1 expression and may inhibit preosteoblast proliferation and differentiation 3. Copy number variants in SNTG1 have been identified in congenital scoliosis patients 4. Additionally, SNTG1 shows differential DNA methylation patterns in ischemic myocardium following extracellular vesicle treatment 5 and has been associated with childhood obesity in genomic studies 6, suggesting broader roles in cellular metabolism and development beyond its established neuronal functions.