SNTG2 (syntrophin gamma 2) is an adapter protein that organizes subcellular localization of various proteins, likely linking receptors to the actin cytoskeleton and dystrophin glycoprotein complex 1. The protein contains PDZ domains enabling binding to neuroligin family proteins and participates in syntrophin complex assembly at the plasma membrane, with particular relevance to central nervous system development 1. Mechanistically, SNTG2 directly interacts with neuroligins 3 and 4X/4Y, interactions that are disrupted by autism-related mutations 1. This suggests impaired SNTG2-neuroligin coupling may contribute to autism etiology. SNTG2 is implicated in neurodevelopmental disorders broadly, identified as a candidate gene in large cohorts with developmental delay and communication deficits 23. Disease associations extend beyond neurodevelopment. SNTG2 variants appear in idiopathic generalized epilepsy gene-interaction networks 4 and exhibit altered DNA methylation patterns in tinnitus 5 and osteoporotic vertebral fractures, where SNTG2 overexpression was the most significantly upregulated gene 6. Preliminary evidence suggests SNTG2 methylation may associate with childhood obesity 7. Clinically, SNTG2 copy number variations and mutations represent potential diagnostic markers for neurodevelopmental and neurological disorders, though further validation in larger cohorts is needed to establish predictive significance.