SNX11 is a phosphoinositide-binding protein localized to endosomal membranes that regulates protein trafficking and membrane homeostasis 1. Its primary function involves sorting cargo proteins from the plasma membrane to lysosomes for degradation via interaction with phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) 2. SNX11 specifically promotes TRPV3 ion channel trafficking from the plasma membrane to lysosomes, thereby downregulating functional TRPV3 levels 3. This mechanism has physiological relevance to thermal sensation; SNX11-knockout mice exhibit enhanced TRPV3 membrane expression and increased heat sensitivity, establishing a novel link between vesicular trafficking and thermal transduction 4. Beyond thermosensing, SNX11 regulates nuclear translocation of the GPCR F2rl1 in neurons, controlling angiogenic signaling 5. SNX11 interacts with V-ATPase subunits to maintain endosomal pH homeostasis, a function critical for viral infection 6. Clinically, SNX11 serves as an essential host factor for pathogenic viruses including SFTSV, dengue virus, hantavirus, and influenza virus, making it a potential broad-spectrum antiviral target 7 6. Genetic studies identify SNX11 as causally associated with endometrial cancer susceptibility 8.