SREK1IP1 encodes a zinc finger domain-containing protein classified within the PTHR31437 family of zinc knuckle (ZCCHC) motif-containing proteins 1. The protein is thought to function in pre-mRNA splicing and RNA methylation 12, with its zinc ion binding capability suggesting potential influence on olfactory signaling 3. SREK1IP1 likely functions as a splicing regulator involved in cellular survival control 4, interacting with serine-arginine-rich splicing regulatory proteins to modulate pre-mRNA maturation 4. Clinically, loss-of-function variants in SREK1IP1 have been identified in isolated congenital anosmia (ICA) patients, occurring in approximately 5% of an ICA cohort, suggesting a role in olfactory development 3. Additionally, reduced SREK1IP1 expression in gastric cancer cells correlates with increased cell proliferation, migration, and invasion, similar to effects observed with SET7/9 knockdown, implicating SREK1IP1 as a potential tumor suppressor gene 5. The protein has also been identified as a candidate gene in colonic diverticulosis genetic predisposition 6. Overall, SREK1IP1 appears critical for both normal olfactory function and cellular growth regulation, with dysfunction contributing to developmental and neoplastic pathologies.