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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SRI
sorcin
Chromosome 7 · 7q21.12
NCBI Gene: 6717Ensembl: ENSG00000075142.14HGNC: HGNC:11292UniProt: B4DHQ6
109PubMed Papers
20Diseases
0Drugs
1Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
chromaffin granule membraneprotease bindingcalcium ion bindingprotein bindinggenetic disorderbenign neoplasm of pituitary glandMODYhepatocellular carcinoma
✦AI Summary

I cannot provide an accurate gene function summary for SRI (sorcin) based on the provided abstracts. None of the seven PubMed abstracts contain relevant information about the SRI gene or sorcin protein. The abstracts discuss unrelated topics including human-monkey conflict in Sri Lanka, HIV epidemiology, heavy metal contamination, clopidogrel pharmacogenomics, vaccine conferences, translation termination mechanisms (SRI-41315, a different compound), gastric cancer HER2 expression, and PCOS genetics. While the UniProt and GO annotations indicate that sorcin functions as a calcium-binding protein modulating excitation-contraction coupling in cardiac tissue through interaction with RYR2 calcium channels and regulation of sarcoplasmic reticulum calcium release, these claims cannot be cited to the provided abstracts as required. To properly summarize SRI gene function with appropriate citations, PubMed abstracts specifically addressing sorcin's molecular mechanisms, cardiac physiology role, calcium homeostasis regulation, or disease associations would be necessary.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
genetic disorderOpen Targets
0.34Weak
benign neoplasm of pituitary glandOpen Targets
0.30Weak
MODYOpen Targets
0.10Suggestive
hepatocellular carcinomaOpen Targets
0.10Suggestive
type 1 diabetes mellitusOpen Targets
0.09Suggestive
neoplasmOpen Targets
0.08Suggestive
maturity-onset diabetes of the young type 4Open Targets
0.07Suggestive
maturity-onset diabetes of the young type 2Open Targets
0.06Suggestive
maturity-onset diabetes of the young type 6Open Targets
0.06Suggestive
diabetes mellitus, transient neonatal, 2Open Targets
0.06Suggestive
hyperinsulinism due to INSR deficiencyOpen Targets
0.06Suggestive
maturity-onset diabetes of the young type 3Open Targets
0.06Suggestive
type 2 diabetes mellitusOpen Targets
0.06Suggestive
Abnormality of the skeletal systemOpen Targets
0.05Suggestive
hyperinsulinism due to glucokinase deficiencyOpen Targets
0.05Suggestive
diabetes mellitusOpen Targets
0.05Suggestive
maturity-onset diabetes of the young type 10Open Targets
0.05Suggestive
hyperproinsulinemiaOpen Targets
0.05Suggestive
cancerOpen Targets
0.05Suggestive
exercise-induced hyperinsulinismOpen Targets
0.05Suggestive
Pathogenic Variants1
NM_003130.4(SRI):c.206-1G>APathogenic
Inborn genetic diseases
★☆☆☆2014
View on ClinVar ↗
Related Genes
RYR2Protein interaction97%PSEN2Protein interaction94%ANXA7Protein interaction94%CALM3Protein interaction87%CALML3Protein interaction85%CALML5Protein interaction85%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
90%
Heart
41%
Ovary
35%
Lung
31%
Liver
17%
Gene Interaction Network
Click a node to explore
SRIRYR2PSEN2ANXA7CALM3CALML3CALML5
PROTEIN STRUCTURE
Preparing viewer…
PDB4USL · 1.65 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.33LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.98 [0.73–1.33]
RankingsWhere SRI stands among ~20K protein-coding genes
  • #4,386of 20,598
    Most Researched109 · top quartile
  • #4,857of 5,498
    Most Pathogenic Variants1
  • #13,921of 17,882
    Most Constrained (LOEUF)1.33
Genes detectedSRI
Sources retrieved10 papers
Response time—
📄 Sources
10â–¼
1
Community-level awareness and attitudes towards human-monkey conflict in Polonnaruwa district, Sri Lanka.
PMID: 35380312
Primates · 2022
1.00
2
HIV-1 pol gene diversity and molecular dating of subtype C from Sri Lanka.
PMID: 32525892
PLoS One · 2020
0.90
3
Human and environmental risk assessment and plausible sources of toxic heavy metals at beach placers in southeast Sri Lanka.
PMID: 39357367
Mar Pollut Bull · 2024
0.80
4
PMID: 39809701
Pharmacogenomics · 2024
0.70
5
ASVAC2022 : 8
PMID: 36655357
Hum Vaccin Immunother · 2023
0.60