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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SRM
spermidine synthase
Chromosome 1 · 1p36.22
NCBI Gene: 6723Ensembl: ENSG00000116649.11HGNC: HGNC:11296UniProt: P19623
72PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
identical protein bindingprotein homodimerization activityspermidine synthase activityprotein bindingAbnormality of the skeletal systemdiabetic neuropathyobesitycolorectal carcinoma
✦AI Summary

Insufficient information provided. The PubMed abstracts supplied do not contain relevant scientific literature about spermidine synthase (SRM gene). The abstracts exclusively discuss super-resolution microscopy techniques (SRM as an acronym for imaging), DNA standard reference materials, proteomics methods, and neurological disease imaging—none of which address the spermidine synthase gene, its enzymatic function, polyamine biosynthesis mechanisms, or disease associations. To provide an evidence-based gene function summary grounded in PubMed literature as required, abstracts specifically investigating spermidine synthase catalytic activity, polyamine metabolism, substrate specificity, regulation, or disease relevance would be necessary. The provided abstracts do not support any factual claims about the SRM gene's biological role, enzymatic kinetics, protein structure, tissue distribution, or clinical significance.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Abnormality of the skeletal systemOpen Targets
0.27Weak
diabetic neuropathyOpen Targets
0.07Suggestive
obesityOpen Targets
0.07Suggestive
colorectal carcinomaOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.04Suggestive
cancerOpen Targets
0.03Suggestive
urinary bladder carcinomaOpen Targets
0.03Suggestive
hepatocellular carcinomaOpen Targets
0.03Suggestive
Townes-Brocks syndromeOpen Targets
0.03Suggestive
liver cancerOpen Targets
0.02Suggestive
posterior cortical atrophyOpen Targets
0.02Suggestive
lung adenocarcinomaOpen Targets
0.02Suggestive
breast cancerOpen Targets
0.02Suggestive
head and neck squamous cell carcinomaOpen Targets
0.02Suggestive
ovarian cancerOpen Targets
0.02Suggestive
prostate cancerOpen Targets
0.02Suggestive
nonpapillary renal cell carcinomaOpen Targets
0.02Suggestive
Alzheimer diseaseOpen Targets
0.02Suggestive
colorectal cancerOpen Targets
0.01Suggestive
squamous cell carcinomaOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
AMD1Shared pathway100%AOC1Protein interaction100%ARG1Protein interaction100%ARG2Protein interaction100%SAT1Protein interaction100%AGMATProtein interaction99%
Tissue Expression6 tissues
Liver
100%
Ovary
93%
Lung
84%
Heart
83%
Brain
64%
Bone Marrow
44%
Gene Interaction Network
Click a node to explore
SRMAMD1AOC1ARG1ARG2SAT1AGMAT
PROTEIN STRUCTURE
Preparing viewer…
PDB2O07 · 1.89 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.59Moderately Constrained
pLIⓘ
0.64Intermediate
Observed/Expected LoF0.38 [0.25–0.59]
RankingsWhere SRM stands among ~20K protein-coding genes
  • #6,588of 20,598
    Most Researched72
  • #4,032of 17,882
    Most Constrained (LOEUF)0.59 · top quartile
Genes detectedSRM
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Super-resolution microscopy demystified.
PMID: 30602772
Nat Cell Biol · 2019
1.00
2
Characterization of NIST human mitochondrial DNA SRM-2392 and SRM-2392-I standard reference materials by next generation sequencing.
PMID: 28460352
Forensic Sci Int Genet · 2017
0.90
3
Assessment of human nuclear and mitochondrial DNA qPCR assays for quantification accuracy utilizing NIST SRM 2372a.
PMID: 35576790
Forensic Sci Int Genet · 2022
0.80
4
Super-resolved fluorescence imaging of peripheral nerve.
PMID: 35864187
Sci Rep · 2022
0.70
5
Navigating challenges in the application of superresolution microscopy.
PMID: 27920217
J Cell Biol · 2017
0.60