STARD13 (StAR Related Lipid Transfer Domain Containing 13) functions as a GTPase-activating protein (GAP) that regulates RhoA and Cdc42 signaling pathways 12. The protein acts as a tumor suppressor across multiple cancer types by modulating cell survival pathways and inducing apoptosis in both p53-dependent and independent manners 1. STARD13 plays a complex role in cancer cell behavior, differentially regulating migration and invasion processes. While it can inhibit 2D cell migration through constitutive RhoA activation, it suppresses invasion by preventing Cdc42-mediated invadopodia formation and matrix degradation 234. The protein is notably absent from mature invadopodia structures, where Cdc42 activation occurs 43. STARD13 expression is frequently downregulated in various cancers including prostate, lung, breast, and ovarian cancers, correlating with poor patient prognosis 235. The gene participates in competing endogenous RNA (ceRNA) networks that inhibit epithelial-mesenchymal transition and metastasis 5. Additionally, STARD13 expression can be regulated by microRNA-mediated mechanisms, such as miR-125b-5p targeting in hepatic stellate cells 6. These findings establish STARD13 as a promising therapeutic target for cancer treatment.