STRBP (spermatid perinuclear RNA binding protein) is a microtubule-associated RNA-binding protein that plays diverse roles in cellular processes and disease pathogenesis. STRBP demonstrates preferential binding to double-stranded RNA over single-stranded forms and specifically interacts with double-stranded satellite RNA structures 1. The protein functions as an RNA editing regulator, interacting with ADAR enzymes and modulating adenosine-to-inosine RNA editing levels 2. In cancer contexts, STRBP acts as an oncogene in triple-negative breast cancer by promoting UBR5-mediated proteasomal degradation of Dicer, leading to dysregulated microRNA biogenesis and enhanced tumor progression 3. STRBP also contributes to epithelial-mesenchymal transition in pancreatic cancer through regulation of alternative splicing when double-stranded satellite RNA binding is disrupted 1. Additionally, STRBP promotes hepatocellular carcinoma cell proliferation and invasion 4. In developmental contexts, decreased STRBP expression is associated with cryptorchidism in Down syndrome patients, suggesting a role in normal testicular development 5. The protein also participates in viral pathogenesis, as it binds to tick-borne encephalitis virus 3'-UTR RNA and may influence viral virulence 6.