STXBP6 (syntaxin binding protein 6) is a SNARE complex component that regulates neuronal and cellular exocytosis by forming non-fusogenic complexes with SNAP25 and STX1A, thereby modulating functional SNARE complex assembly and negatively regulating exocytosis 1. Beyond its classical vesicle trafficking role, STXBP6 exhibits pleiotropic functions across multiple disease contexts. In neurology, STXBP6 mutations cause developmental epileptic encephalopathy and autism spectrum disorders through disrupted synaptic vesicle exocytosis 1. In autoimmunity, STXBP6 represents a genetic risk factor for type 1 diabetes, particularly late-onset disease; proinflammatory cytokines upregulate STXBP6 expression, which impairs insulin secretion and increases beta cell apoptosis 2. STXBP6 also associates with immunoglobulin A deficiency in HLA-risk allele carriers 3 and Parkinson disease dementia 4. In cancer biology, STXBP6 functions as an oncogenic driver, promoting ovarian cancer growth and metastasis through PI3K/AKT-dependent lipid metabolism reprogramming 5. Additionally, STXBP6 negatively regulates PD-L1 expression via IRF1 cytoplasmic retention, forming a positive feedback loop that modulates anti-tumor immunity 6. STXBP6 methylation patterns correlate with non-small cell lung cancer stage and patient survival 7.