SUPT7L (SPT7 like) encodes a component of the STAGA transcriptional coactivator complex, which functions as a histone acetyltransferase involved in regulating RNA polymerase II-dependent transcription 1. SUPT7L serves as a scaffold protein that interacts with other STAGA subunits and facilitates complex assembly; it forms heterodimeric interactions with TAF10 through histone fold domains and participates in nuclear localization of TAF10 23. The protein regulates gene expression and is involved in DNA repair pathway components and genome stability maintenance 4. Loss-of-function variants in SUPT7L cause Fischer-Zirnsak progeroid syndrome, a developmental disorder characterized by intrauterine growth retardation, generalized lipodystrophy, and progeroid features 4. Disease-associated variants (missense and frameshift mutations) lead to aberrant splicing, SUPT7L protein absence, and elevated DNA damage in dermal fibroblasts; wildtype SUPT7L overexpression normalizes DNA damage levels, establishing a direct link between SUPT7L function and genome stability 4. Beyond Mendelian disease, SUPT7L shows altered expression in human malignancies. It functions as a prospective epigenetic oncogene in hepatocellular carcinoma and is associated with tumor stage mycosis fungoides progression 56. SUPT7L expression also correlates with survival outcomes in esophageal squamous cell carcinoma 7, suggesting broader roles in tumorigenesis alongside its essential transcriptional regulatory functions.