SYBU (syntabulin) is a critical component of kinesin motor-adapter complexes that facilitates anterograde axonal transport of active zone components and mitochondria, playing essential roles in neuronal development and synaptic function. The protein is involved in vesicular transport mechanisms and localizes to the Golgi apparatus as a membrane-bound protein with transmembrane domains 1. SYBU contributes to activity-dependent presynaptic assembly during neuronal development and is crucial for proper mitochondrial distribution in axons and synapses 2. Disease relevance studies have identified SYBU as one of 12 potentially novel risk loci for Parkinson's disease through multi-ancestry genome-wide association studies, with variants detected in both manifest PD patients and individuals in the prodromal stage 34. Additionally, SYBU protein levels are significantly decreased in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease with dementia, and dementia with Lewy bodies, with this reduction correlating with cognitive impairment and rate of cognitive decline 5. The protein also shows differential expression in various pathological conditions, including lacrimal gland carcinoma and polycystic ovary syndrome, suggesting broader roles in cellular transport and disease processes 67.