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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
SYNC
syncoilin, intermediate filament protein
Chromosome 1 Β· 1p35.1
NCBI Gene: 81493Ensembl: ENSG00000162520.16HGNC: HGNC:28897UniProt: Q9H7C4
21PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingintermediate filament-based processcytosolZ discspermatoceletype 2 diabetes mellitushypothyroidismAbnormality of the skeletal system
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

syncoilin, intermediate filament protein

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
spermatoceleOpen Targets
0.32Weak
type 2 diabetes mellitusOpen Targets
0.13Weak
hypothyroidismOpen Targets
0.05Suggestive
Abnormality of the skeletal systemOpen Targets
0.03Suggestive
Alzheimer diseaseOpen Targets
0.03Suggestive
ependymomaOpen Targets
0.02Suggestive
ovarian carcinomaOpen Targets
0.02Suggestive
colorectal cancerOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.02Suggestive
non-small cell lung carcinomaOpen Targets
0.02Suggestive
Tetralogy of FallotOpen Targets
0.02Suggestive
glioblastoma multiformeOpen Targets
0.01Suggestive
childhood supratentorial ependymomaOpen Targets
0.01Suggestive
hypertrophic cardiomyopathyOpen Targets
0.01Suggestive
Duchenne muscular dystrophyOpen Targets
0.01Suggestive
myxosarcomaOpen Targets
0.01Suggestive
neuromuscular diseaseOpen Targets
0.01Suggestive
myopathyOpen Targets
0.01Suggestive
papillary thyroid carcinomaOpen Targets
0.01Suggestive
psoriasisOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
VIMProtein interaction94%DESProtein interaction88%DTNAProtein interaction88%SYNMProtein interaction88%DMDProtein interaction79%DTNBProtein interaction79%
Tissue Expression6 tissues
Heart
100%
Lung
24%
Brain
13%
Ovary
9%
Liver
2%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
SYNCVIMDESDTNASYNMDMDDTNB
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9H7C4
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.01LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.77 [0.59–1.01]
RankingsWhere SYNC stands among ~20K protein-coding genes
  • #14,029of 20,598
    Most Researched21
  • #9,871of 17,882
    Most Constrained (LOEUF)1.01
Genes detectedSYNC
Sources retrieved0 papers
Response timeβ€”