TACR3 encodes tachykinin receptor 3 (NK3R), a G protein-coupled receptor with primary affinity for neuromedin-K, though it also binds substance K/neurokinin A and substance P 1. Ligand binding activates dual signaling pathways: phospholipase C activation via G(q) proteins and adenylate cyclase-mediated cAMP increase 2. Beyond its well-established reproductive function, TACR3 is widely expressed throughout the nervous system and regulates diverse physiological processes including mood, chr4 pain, learning, memory, and neurological conditions such as Alzheimer's and Parkinson's diseases 3. Clinically, loss-of-function TACR3 mutations cause hypogonadotropic hypogonadism with or without anosmia, inherited in autosomal dominant, recessive, or oligogenic patterns, making TACR3 a priority screening target alongside GNRHR in pubertal delay cases 45. Notably, TACR3 mutations appear rare in idiopathic central precocious puberty 6. Recent evidence suggests TACR3 involvement in hypoxic-ischemic encephalopathy through alternative splicing mechanisms 7, and differential TACR3 expression was identified as a biomarker in sepsis-induced acute lung injury 8. These findings indicate TACR3 functions beyond reproduction across multiple organ systems.