TAS2R60 is a G protein-coupled bitter taste receptor involved in chemosensory perception. It functions as a gustducin-linked receptor that detects bitter compounds and activates downstream signaling through alpha-gustducin, phospholipase C-beta-2, and the ion channel TRPM5. TAS2R60 is expressed in taste tissues and demonstrates extraoral expression in human skin, with expression levels varying by sex, age, and sun exposure 1. The receptor shows genetic association with individual differences in bitter taste perception of various stimuli, including the protease inhibitor Kaletra 2, and variation in basil flavor perception 3. Beyond taste, TAS2R60 has emerged as clinically significant in neurodegeneration and oral health. Genetic variants in TAS2R60 show association with Alzheimer's disease risk in African Americans; SNPs rs117771145 and rs10228407 linked to TAS2R60 downregulation correlate with altered expression of proteins EPHB6 and ADGRB3 implicated in neurological pathways [PMID:39284855; 43]. Additionally, genetic variants in TAS2R60 associate with severe early childhood caries and alter plaque microbial composition 5, suggesting roles in oral immunity and host-microbial interactions. However, the specific bitter ligand for TAS2R60 remains unidentified 6.