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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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TBC1D3B
TBC1 domain family member 3B
Chromosome 17 Β· 17q12
NCBI Gene: 414059Ensembl: ENSG00000274808.6HGNC: HGNC:27011UniProt: A6NDS4
9PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
GTPase activator activityendosomeplasma membranemembranecholelithiasisprostate cancerlung adenocarcinomaneoplasm
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

TBC1 domain family member 3B

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜8
cholelithiasisOpen Targets
0.02Suggestive
prostate cancerOpen Targets
0.01Suggestive
lung adenocarcinomaOpen Targets
0.00Suggestive
cancerOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
glioma susceptibility 1Open Targets
0.00Suggestive
urinary bladder cancerOpen Targets
0.00Suggestive
urinary bladder carcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
USP32Protein interaction75%
Tissue Expression6 tissues
Liver
100%
Ovary
98%
Lung
97%
Brain
24%
Bone Marrow
0%
Heart
0%
Gene Interaction Network
Click a node to explore
TBC1D3BUSP32
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt A6NDS4
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.46Moderately Constrained
pLIβ“˜
0.93Intolerant
Observed/Expected LoF0.00 [0.00–0.46]
RankingsWhere TBC1D3B stands among ~20K protein-coding genes
  • #17,467of 20,598
    Most Researched9
  • #2,565of 17,882
    Most Constrained (LOEUF)0.46 Β· top quartile
Genes detectedTBC1D3B
Sources retrieved0 papers
Response timeβ€”