TBXA2R (thromboxane A2 receptor) is a G protein-coupled receptor that inhibits adenylyl cyclase and functions as a thromboxane A2 receptor involved in inflammatory responses and vascular regulation. The receptor positively regulates vasoconstriction, blood pressure, and cytosolic calcium signaling while negatively regulating cell migration during angiogenesis 1. TBXA2R operates through G protein-coupled receptor signaling pathways and can be activated not only by thromboxane A2 but also by F2-isoprostanes generated during oxidative stress 1. Functionally, TBXA2R serves as a scaffold protein through PDZ domain interactions with growth factor receptors, potentially modulating heterotrimeric G-protein signaling 2. Clinically, TBXA2R polymorphisms are associated with asthma susceptibility and phenotypes; specific risk alleles correlate with elevated IgE levels, eosinophilic inflammation, and reduced lung function, also predicting poor response to leukotriene receptor antagonist therapy 34. TBXA2R polymorphisms additionally associate with ischemic stroke risk 5. In cancer biology, elevated TBXA2R expression in breast tumors correlates with aggressive grade 3 disease and significantly shorter disease-free survival 6. In pulmonary fibrosis, TBXA2R upregulation in lung fibroblasts drives persistent myofibroblast activation through F2-isoprostane signaling, and TBXA2R antagonism protects against fibrosis development and promotes resolution 1. Germline mutations in TBXA2R cause platelet-type bleeding disorder 13.