TCHP (trichoplein keratin filament binding) is a multifunctional protein with roles in cytoskeletal organization, ciliogenesis regulation, and cellular homeostasis. Structurally, TCHP localizes to centriolar satellites and keratin filaments, where it acts as a 'capping' or 'branching' protein for K8/K18 filaments in epithelial cells 12. TCHP functions as a negative regulator of ciliogenesis 3, and mechanistically mediates cilia disassembly through Aurora A signaling during decidualization 4. Additionally, TCHP binds and stabilizes PCM1 at centriolar satellites, controlling autophagy and endothelial cell function; loss of TCHP impairs autophagic flux and leads to p62 accumulation, with reduced TCHP levels detected in coronary artery disease patients 5. At the disease level, TCHP has tumor suppressor properties, inhibiting cell growth in bladder and prostate cancer cells through HSPB1 downregulation [UniProt]. Notably, a genetic variant in TCHP exon 4 (an Asian-specific cis-sQTL) modulates Graves' disease risk in East Asian populations 6. TCHP's role in endothelial homeostasis and its association with disease susceptibility highlight its importance beyond epithelial cytoskeletal organization, suggesting potential therapeutic targets in cardiovascular and autoimmune conditions.