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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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TDRP
testis development related protein
Chromosome 8 · 8p23.3
NCBI Gene: 157695Ensembl: ENSG00000180190.13HGNC: HGNC:26951UniProt: Q86YL5
16PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
spermatogenesisnucleuscytosolcytoplasmneurodegenerative diseasemusculoskeletal system diseaseAbruptio Placentaerespiratory tract infectious disorder
✦AI Summary

Insufficient information available. The provided PubMed abstracts exclusively address epidemiology, classification, and treatment of brain and central nervous system tumors (glioblastomas, meningiomas, and IDH-mutant gliomas), with no discussion of TDRP (testis development related protein) or its biological function. The abstracts contain no data supporting the characterization of TDRP's primary function, mechanism of action, cellular localization, or disease relevance. While UniProt annotations suggest TDRP contributes to sperm motility and localizes to cytoplasm, cytosol, mitochondrion, nucleus, and participates in spermatogenesis, these claims cannot be grounded in the provided abstracts. To generate an evidence-based summary, PubMed abstracts directly investigating TDRP expression, protein-protein interactions, knockout studies, or clinical associations with male fertility or spermatogenesis would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.37Weak
Abruptio PlacentaeOpen Targets
0.28Weak
musculoskeletal system diseaseOpen Targets
0.28Weak
respiratory tract infectious disorderOpen Targets
0.26Weak
alcohol drinkingOpen Targets
0.21Weak
premature birthOpen Targets
0.11Weak
azoospermiaOpen Targets
0.11Weak
hypertrophic cardiomyopathyOpen Targets
0.09Suggestive
spermatogenic failure 24Open Targets
0.07Suggestive
spermatogenic failure, X-linked, 5Open Targets
0.07Suggestive
spermatogenic failure 72Open Targets
0.07Suggestive
spermatogenic failure 18Open Targets
0.07Suggestive
spermatogenic failure 27Open Targets
0.07Suggestive
spermatogenic failure 46Open Targets
0.07Suggestive
spermatogenic failure 51Open Targets
0.07Suggestive
spermatogenic failure 19Open Targets
0.07Suggestive
spermatogenic failure 43Open Targets
0.07Suggestive
spermatogenic failure 45Open Targets
0.07Suggestive
spermatogenic failure 49Open Targets
0.07Suggestive
spermatogenic failure 82Open Targets
0.07Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
ACRV1Shared pathway100%SPAG4Shared pathway100%SSX1Shared pathway100%SPAG11BShared pathway100%MYCBPShared pathway100%SPANXA1Shared pathway100%
Tissue Expression6 tissues
Ovary
100%
Liver
98%
Lung
28%
Heart
25%
Brain
24%
Bone Marrow
5%
Gene Interaction Network
Click a node to explore
TDRPACRV1SPAG4SSX1SPAG11BMYCBPSPANXA1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q86YL5
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.82LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.19 [0.74–1.82]
RankingsWhere TDRP stands among ~20K protein-coding genes
  • #15,413of 20,598
    Most Researched16
  • #16,667of 17,882
    Most Constrained (LOEUF)1.82
Genes detectedTDRP
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016-2020.
PMID: 37793125
Neuro Oncol · 2023
1.00
2
Brain and other central nervous system tumor statistics, 2021.
PMID: 34427324
CA Cancer J Clin · 2021
0.90
3
Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.
PMID: 38695575
Neuro Oncol · 2024
0.80
4
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019.
PMID: 36196752
Neuro Oncol · 2022
0.70
5
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.
PMID: 34608945
Neuro Oncol · 2021
0.60