Based on limited published evidence, TEX13D is an X-linked gene expressed specifically or predominantly in male germ cells with developmentally regulated transcription. According to GO annotations, TEX13D has mRNA binding capacity. TEX13D encodes a protein containing a conserved ~145 amino acid domain and a C-terminal zinc finger-RanBP2-like domain. Functionally, TEX13D exhibits transcriptional repressor activity, likely operating as a transcription cofactor and/or RNA binding protein in male germ cell development 1. Recent screening identified rare variants in TEX13D among infertile men, though the pathogenic significance remains unclear as variants were also detected in fertile controls 2.