TFG (trafficking from ER to golgi regulator) is essential for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus 1. The protein plays a crucial role in maintaining normal dynamic function of the endoplasmic reticulum and its associated microtubules 23. TFG functions as a regulator of the secretory pathway, facilitating proper vesicle-mediated transport between cellular compartments. Disease relevance includes associations with hereditary motor and sensory neuropathy (Okinawa type) and autosomal recessive spastic paraplegia 57. Clinical significance is highlighted by the identification of homozygous likely deleterious variants in TFG in patients with compatible neuromuscular phenotypes 4. The gene has also been reported as a translocation variant in acute promyelocytic leukemia cases, though this represents a rare occurrence 5. TFG's critical role in intracellular trafficking makes it important for cellular homeostasis, and mutations can lead to various neurological disorders affecting motor and sensory functions.