TGM7 encodes transglutaminase 7 (TG7), a protein-glutamine gamma-glutamyltransferase that catalyzes cross-linking of proteins and conjugation of polyamines to proteins 1. Located on chromosome 15, TGM7 is part of a tandem cluster with TGM5 and EPB42, showing widespread tissue expression 1. TGM7 appears evolutionary constrained, as homozygous loss-of-function variants have not been identified in human populations, suggesting important physiological roles 2. In disease contexts, TGM7 mutations are notably elevated in radiation-associated bladder tumors (21.4% frequency) compared to primary bladder cancers, potentially reflecting radiation-induced genomic damage 3. TGM7 also appears as a prognostic factor in high-grade neuroendocrine lung carcinoma 4 and was identified as a recurrent fusion partner (UBAP1-TGM7) unique to clear cell ovarian cancer (10% of cases) 5. Functionally, TGM7 silencing in testicular germ cell tumors reduces cell viability by up to 48% and triggers p53-independent apoptotic and inflammatory responses 6, establishing TGM7 as a potential therapeutic target in cancer.