THBS3 (thrombospondin 3) is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions by binding to fibrinogen, fibronectin, laminin, and type V collagen. The gene spans 23 exons and encodes a 956 amino acid polypeptide containing seven calcium-binding type III repeats, four EGF-like type II repeats, and terminal domains 1. THBS3 functions through extracellular matrix remodeling and focal adhesion signaling pathways, as demonstrated by its role in cancer-associated fibroblast-cancer cell crosstalk in ovarian cancer 2. Disease relevance includes multiple cancer types: elevated THBS3 predicts poor overall survival in clear cell renal cell carcinoma and associates with stem cell-like features in gastric cancer 34. In osteosarcoma, high THBS3 expression strongly correlates with metastasis at diagnosis and worse survival outcomes 5. Conversely, reduced THBS3 expression in peripheral blood associates with acute myocardial infarction risk, where decreased protein levels independently increased AMI probability 4.076-fold 6. THBS3 was also identified as a causative gene in gout pathogenesis through protein-interaction network analysis 7. Clinically, THBS3 shows promise as both a prognostic biomarker and therapeutic target across diverse conditions, though its expression patterns differ contextually between cardiovascular protection and cancer promotion.