Based on limited published evidence, TIMM10B is a component of the TIM22 complex that mediates import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex functions as a twin-pore translocase utilizing membrane potential as the driving force, with TIMM10B potentially acting as a docking point for the 70 kDa chaperone complex guiding target proteins through the mitochondrial intermembrane space. Recent evidence suggests TIMM10B may have broader roles in tumor-associated neutrophil function and triple-negative breast cancer progression, with elevated expression correlating with poor survival 1.