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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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TM2D2
TM2 domain containing 2
Chromosome 8 Β· 8p11.22
NCBI Gene: 83877Ensembl: ENSG00000169490.18HGNC: HGNC:24127UniProt: Q9BX73
13PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingmembraneAbnormality of the skeletal systemneurodegenerative diseasesialolithiasislymphatic malformation 8
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

TM2 domain containing 2

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Abnormality of the skeletal systemOpen Targets
0.38Weak
neurodegenerative diseaseOpen Targets
0.37Weak
sialolithiasisOpen Targets
0.05Suggestive
lymphatic malformation 8Open Targets
0.04Suggestive
hereditary angioedemaOpen Targets
0.04Suggestive
hereditary angioedema with normal C1InhOpen Targets
0.04Suggestive
lymphatic malformation 11Open Targets
0.04Suggestive
LipedemaOpen Targets
0.03Suggestive
Abnormal nasolacrimal system morphologyOpen Targets
0.02Suggestive
trigeminal nerve diseaseOpen Targets
0.02Suggestive
infectionOpen Targets
0.01Suggestive
breast neoplasmOpen Targets
0.01Suggestive
Alzheimer diseaseOpen Targets
0.01Suggestive
pancreatic ductal adenocarcinomaOpen Targets
0.01Suggestive
infectious diseaseOpen Targets
0.00Suggestive
metabolic diseaseOpen Targets
0.00Suggestive
invasive breast ductal carcinomaOpen Targets
0.00Suggestive
pancreatic carcinomaOpen Targets
0.00Suggestive
meningococcal infectionOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TM2D1Protein interaction98%
Tissue Expression6 tissues
Brain
100%
Liver
85%
Heart
83%
Ovary
79%
Lung
75%
Bone Marrow
43%
Gene Interaction Network
Click a node to explore
TM2D2TM2D1
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9BX73
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.30LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.84 [0.56–1.30]
RankingsWhere TM2D2 stands among ~20K protein-coding genes
  • #16,332of 20,598
    Most Researched13
  • #13,657of 17,882
    Most Constrained (LOEUF)1.30
Genes detectedTM2D2
Sources retrieved0 papers
Response timeβ€”