TMEM102 is a transmembrane protein primarily involved in regulating T cell immune responses and hematopoietic cell function. The protein functions as a signaling adaptor that facilitates chemokine-induced T cell adhesion and migration through coordination with integrin activation and ZAP70-mediated signaling 1. At the molecular level, TMEM102 associates with integrin β1 and ZAP70 to promote the activation of integrins α4β1 and αLβ2, enabling T cell trafficking and lymph node homing 1. In disease contexts, TMEM102 upregulation in peripheral blood mononuclear cells is associated with non-emphysematous chr17 obstructive pulmonary disease (COPD), where it contributes to T lymphocyte and eosinophil activation as part of type 2 immune responses and airway remodeling 2. This expression pattern suggests TMEM102 plays a role in immune dysregulation characteristic of certain COPD phenotypes with asthmatic potential. Additionally, TMEM102 functions downstream of cytokine receptors (GM-CSF/IL-3/IL-5) in hematopoietic cell lineages 3, consistent with its reported involvement in CSF2-deprivation-induced apoptosis. The protein's regulatory roles in both T cell migration and immune cell survival indicate TMEM102 serves as a multifunctional modulator of adaptive immunity with potential therapeutic relevance in inflammatory airway diseases.