Based on limited published evidence, TMEM145 is a transmembrane protein with a Golgi dynamics domain belonging to the GOST (GOLD domain seven-transmembrane helix) protein family 1. TMEM145 functions as a key component of outer hair cell stereocilia in the cochlea, specifically localizing to tectorial membrane-attachment crowns and horizontal top connectors 2. The protein mediates secretion of stereocilin and tubby, which lack transmembrane domains, and is essential for auditory function; Tmem145 knockout mice exhibit profound hearing impairment and loss of these stereociliary structures 2. TMEM145 likely serves as a membrane trafficking and secretion chaperone for cargo proteins similar to its GOST family homolog WLS 1.