TMEM150A (transmembrane protein 150A), also known as DRAM5, is a plasma membrane-localized regulator of phosphatidylinositol phosphate metabolism. Its primary function involves modulating phosphatidylinositol 4-kinase (PI4K) complex composition at the plasma membrane to regulate PI(4,5)P2 synthesis 1. Mechanistically, TMEM150A reduces the association of TTC7 with the PI4KIIIα-EFR3 complex while maintaining PI4K plasma membrane localization, demonstrating plasticity in controlling this enzymatic complex 1. TMEM150A also functions as a nutrient-responsive autophagy regulator within the DRAM family, modulating autophagic flux and cell survival during nutrient deprivation 2. In immune signaling, TMEM150A suppression enhances LPS-induced TLR4 cytokine responses, suggesting it normally restrains inflammatory signaling through PI(4,5)P2 homeostasis 3. Clinically, TMEM150A is significantly overexpressed in glioblastoma and glioma tissues, correlating with poor prognosis, increased cell proliferation and migration, and altered immune microenvironment composition 45. TMEM150A suppression inhibits glioma progression through epithelial-mesenchymal transition modulation, identifying it as a potential therapeutic target 5.