TMEM182 (transmembrane protein 182) is a transmembrane protein with pleiotropic functions across multiple biological systems. In cardiac development, TMEM182 inhibits myocardial differentiation of human induced pluripotent stem cells by maintaining activated Wnt/β-catenin signaling through increased integrin-linked kinase (ILK) expression, thereby suppressing cardiomyocyte differentiation 1. In oral squamous cell carcinoma, TNF-α induces miR-450a, which suppresses TMEM182 expression and promotes tumor cell motility through ERK1/2 signaling activation, indicating TMEM182 acts as a tumor suppressor in this context 2. TMEM182 has been associated with multiple complex traits including smoking behavior (rs12616219 near TMEM182 replicated in smoking-related phenotypes) 3 and sun-seeking behavior in large genome-wide association studies 4. A TMEM182 polymorphism (rs141764639) associates with central obesity risk in Korean populations through TNF-α upregulation 5. Additionally, TMEM182 is implicated in colorectal cancer chemotherapy resistance, with upregulated expression in FOLFOX-resistant tumors 6, and appears in competing endogenous RNA networks affecting lung adenocarcinoma progression 7. While TMEM182 variants show suggestive association with glaucoma phenotypes, functional significance remains unclear 8. Overall, TMEM182 functions as a context-dependent regulator of differentiation and inflammatory processes.