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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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TRA
T cell receptor alpha locus
Chromosome 14 · 14q11.2
NCBI Gene: 6955
131PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence
alpha-beta T cell receptor complexdetection of tumor cellT cell mediated cytotoxicity directed against tumor cell targetsignaling receptor activity
✦AI Summary

Based on the provided abstracts, there is insufficient information to provide a comprehensive gene function summary for the TRA (T cell receptor alpha locus) gene. The abstracts primarily focus on unrelated medical procedures involving transradial access (TRA) for cardiovascular interventions 1234, transversus abdominis muscle evaluation 5, and arsenic exposure studies 6. Only one abstract provides relevant information about T cell receptor alpha chains, showing that germline-like TRA chains are shared between autoreactive T cells in peripheral blood and pancreas-infiltrating T cells in type 1 diabetes patients 7. This study demonstrates that approximately 29% of islet antigen-reactive TRA junctions match those found in pancreatic tissue, with these sequences being largely public, enriched for TRAV41 usage, and showing germline-encoded features that may facilitate cross-reactivity 7. However, the provided abstracts lack fundamental information about TRA's primary function in T cell receptor formation, antigen recognition mechanisms, or broader disease relevance beyond diabetes autoimmunity. Additional literature specifically addressing T cell receptor alpha locus function would be required for a complete gene summary.

Sources cited
1
TRA chains are shared between autoreactive T cells in blood and pancreas, with ~29% of islet antigen-reactive TRA junctions matching pancreatic tissue sequences, enriched for TRAV41 usage and germline-encoded features
PMID: 38871688
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
CENPUProtein interaction100%CENPAProtein interaction100%CENPOProtein interaction100%CENPKProtein interaction100%CENPTProtein interaction100%CENPQProtein interaction100%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
TRACENPUCENPACENPOCENPKCENPTCENPQ
PROTEIN STRUCTURE
?
No structure data available
Structures require a reviewed Swiss-Prot entry.
RankingsWhere TRA stands among ~20K protein-coding genes
  • #3,576of 20,598
    Most Researched131 · top quartile
Genes detectedTRA
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Radial Access Techniques.
PMID: 35346447
Neurosurg Clin N Am · 2022
1.00
2
Radial Access Intervention.
PMID: 35346448
Neurosurg Clin N Am · 2022
0.90
3
Transradial Artery Access Complications.
PMID: 31672030
Circ Cardiovasc Interv · 2019
0.80
4
The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma.
PMID: 17124010
Stem Cells · 2007
0.70
5
Measuring transversus abdominis activity using pressure biofeedback unit-A technical report.
PMID: 37395304
Physiother Res Int · 2023
0.60