TRPV2 is a calcium-permeable, non-selective cation channel that functions as a mechanosensor and thermosensor, activated by high temperatures (>52°C), mechanical stress, and various ligands 1. Under resting conditions, TRPV2 predominantly resides in the endoplasmic reticulum but translocates to the plasma membrane upon stimulation by phosphatidylinositol 3-kinase-activating ligands or mechanical stress 1. The channel plays critical roles in immune cell function, particularly in B cell activation where it facilitates immunological synapse formation, membrane depolarization, and cytoskeletal remodeling 2. TRPV2 expression correlates with influenza-specific antibody production and is dysregulated in systemic lupus erythematosus 2. In cancer biology, TRPV2 promotes melanoma invasiveness and metastasis by localizing to leading edges of migrating cells and regulating calcium-dependent calpain activation and talin cleavage 3. The channel also serves as an antiviral target, as the interferon-stimulated gene TRIM21 induces TRPV2 degradation through K48-linked ubiquitination, thereby limiting viral infection and spread 4. TRPV2 is involved in pain sensation pathways as part of the nociceptor network 5, highlighting its diverse physiological roles in mechanosensation, immune responses, and cellular motility.