HomeAboutRankingsData Sources
© 2026 GeneE
🧬
GeneE
2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
TTC23L
tetratricopeptide repeat domain 23 like
Chromosome 5 · 5p13.2
NCBI Gene: 153657Ensembl: ENSG00000205838.15HGNC: HGNC:26355UniProt: A0A3B3IS63
21PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingresponse to endoplasmic reticulum stresscentrosomespindleesophageal ulcersialolithiasishair colormalunion fracture
✦AI Summary

Based on limited published evidence, TTC23L encodes a tetratricopeptide repeat domain protein involved in protein binding and endoplasmic reticulum (ER) stress response. A genome-wide association study identified TTC23L as associated with 3-aminoisobutyrate urinary metabolite levels (rs36071744, P = 2.97 × 10⁻¹⁰) 1. Related studies suggest tetratricopeptide repeat proteins, including potential orthologs, may regulate ER stress chaperones and cellular stress responses 2. Further functional characterization is needed to establish TTC23L's specific molecular mechanisms.

Sources cited
1
TTC23L SNP rs36071744 associated with 3-aminoisobutyrate urinary metabolite levels in genome-wide association meta-analysis
PMID: 40595242
2
Tetratricopeptide repeat domain proteins regulate ER stress chaperones and cellular stress responses during cytokinesis
PMID: 25751302
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
esophageal ulcerOpen Targets
0.28Weak
sialolithiasisOpen Targets
0.18Weak
hair colorOpen Targets
0.06Suggestive
malunion fractureOpen Targets
0.04Suggestive
ankylosing spondylitisOpen Targets
0.04Suggestive
hyperpituitarismOpen Targets
0.04Suggestive
glaucomaOpen Targets
0.04Suggestive
open-angle glaucomaOpen Targets
0.04Suggestive
Respiratory insufficiencyOpen Targets
0.03Suggestive
kidney failureOpen Targets
0.03Suggestive
hypothyroidismOpen Targets
0.02Suggestive
irritable bowel syndromeOpen Targets
0.02Suggestive
ovarian neoplasmOpen Targets
0.02Suggestive
pericarditisOpen Targets
0.02Suggestive
diabetes mellitusOpen Targets
0.02Suggestive
deficiency anemiaOpen Targets
0.02Suggestive
actinic keratosisOpen Targets
0.02Suggestive
mastitisOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
urinary bladder cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
IQCEProtein interaction76%FICDShared pathway50%NRBF2Shared pathway50%CREB3L3Shared pathway50%TMEM259Shared pathway50%ERP27Shared pathway50%
Tissue Expression6 tissues
Brain
100%
Ovary
64%
Liver
50%
Lung
28%
Heart
26%
Bone Marrow
6%
Gene Interaction Network
Click a node to explore
TTC23LIQCEFICDNRBF2CREB3L3TMEM259ERP27
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q6PF05
View on AlphaFold ↗
RankingsWhere TTC23L stands among ~20K protein-coding genes
  • #14,055of 20,598
    Most Researched21
Genes detectedTTC23L
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Meta-analysis of urinary metabolite GWAS studies identifies novel genome-wide significant loci.
PMID: 40595242
Sci Rep · 2025
1.00
2
FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones.
PMID: 25751302
Cell Cycle · 2015
0.50