TTI2 (TELO2 interacting protein 2) is an essential component of the conserved Triple T (TTT) complex that serves as a specialized co-chaperone for phosphatidylinositol 3-kinase-related protein kinases (PIKKs) 1. The TTT complex, comprising TELO2, TTI1, and TTI2, modulates the activity, maturation, and stability of critical PIKKs including mTOR, ATM, and ATR by facilitating their proper folding and assembly in cooperation with HSP90 and the R2TP complex 21. Structurally, TTI2 forms an elongated helical repeat structure and binds to the C-terminal end of TTI1 within the TTT complex 3. The complex is essential for DNA damage response pathways and cellular resistance to ionizing radiation, UV, and mitomycin C 3. TTI2 dysfunction has significant disease relevance, as bi-allelic variants cause autosomal recessive intellectual developmental disorder with microcephaly, short stature, and movement disorders 1. Additionally, TTI2 has been implicated as a quantitative trait gene affecting adult hippocampal neurogenesis and glucose metabolism, with heterozygous mutations causing dysglycemia and reduced neurogenesis 4. The protein's role in PIKK stability makes it clinically significant as a potential therapeutic target, with recent evidence suggesting the TTT complex may be targeted by repurposed drugs like ivermectin for cancer therapy 5.