TULP2 is a member of the tubby-like protein family characterized by a conserved C-terminal tubby domain that binds phosphoinositides 1. The protein is primarily expressed in retinal tissue 2 and localizes to cilia, where it plays a role in ciliary protein trafficking 3. However, TULP2's specific ciliary functions remain partially unclear; while it can only partially rescue defective ciliary localization of signaling molecules like ARL13B and GPR161 in TULP3-knockout cells—unlike TULP3 and TUB which provide full rescue—TULP2 likely mediates other unknown molecular roles in ciliary biology 3. TULP2 protein stability is regulated through an acetylation switch mechanism involving p300-mediated acetylation and HDAC1-mediated deacetylation of conserved lysine residues 1. In disease contexts, TULP2 maps to chromosome 19.1 within the minimal interval for cone-rod dystrophy and represents a candidate gene for retinal degeneration 2. Additionally, TULP2 variants have been identified as candidate causal mutations in congenital glaucoma cases lacking mutations in established disease genes 4. Recent evidence suggests TULP2 may also have roles in myocardial injury response, as it was identified as an upregulated diagnostic marker gene in myocardial infarction models 5. Overall, while TULP2's precise molecular function remains incompletely characterized, its ciliary localization and retinal expression implicate it in vision-related processes.