TXLNG (taxilin gamma) is a multifunctional protein involved in transcriptional regulation and cellular organization. Its primary function involves inhibiting ATF4-mediated transcription through protein-protein interactions, forming inactive dimers that cannot bind DNA 1. TXLNG demonstrates significant metabolic regulatory roles, improving insulin resistance in obese subjects by reducing pro-inflammatory factors IL-6 and TNF-α, decreasing adipocyte size, and enhancing glucose uptake through inhibition of ATF4 transcriptional activity 1. At the cellular level, TXLNG localizes to subdistal appendages of mother centrioles, where it forms complexes with α-taxilin through coiled-coil domains and is essential for centriolar subdistal appendage assembly and microtubule organization 2. TXLNG also participates in endoplasmic reticulum stress responses, with its GSK-3β-dependent downregulation triggering unfolded protein responses and subsequent apoptotic and autophagic pathways 3. Clinically, TXLNG has emerged as a potential biomarker for Group I pulmonary hypertension, showing upregulation in patient samples 4. Additionally, microdeletions encompassing TXLNG contribute to Nance-Horan syndrome phenotypes 5. The protein's involvement in bone physiology through ATF4-dependent pathways and its role in neurodegenerative diseases highlight its broad physiological significance 36.