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GeneE
50 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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UBC
ubiquitin C
Chromosome 12 · 12q24.31
NCBI Gene: 7316Ensembl: ENSG00000150991.17HGNC: HGNC:12468UniProt: P0CG48
1,371PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
RESEARCH IMPACT
Highly StudiedTrending
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
extracellular exosomeprotein bindingnucleusGO:0005615HIV infectionlisteriosiscancerdengue disease
✦AI Summary

The abstracts provided do not contain information about the UBC (ubiquitin C) gene function. The abstracts instead focus on urothelial bladder cancer (also abbreviated as UBC), which is unrelated to the ubiquitin C gene. The studies discuss cancer risk factors, treatment strategies, and biomarkers for bladder cancer 12345678. Without relevant abstracts describing the molecular functions of ubiquitin C, I cannot provide a scientifically grounded summary of this gene's primary function, mechanism, disease relevance, or clinical significance. Additional literature specifically addressing ubiquitin C would be required to generate an accurate functional summary.

Sources cited
1
Study focuses on BRCA mutations in breast cancer, not ubiquitin C gene
PMID: 20104584
2
Reviews risk factors for urothelial bladder cancer, not ubiquitin C gene
PMID: 39063530
3
Discusses epidemiology of urothelial bladder cancer, not ubiquitin C gene
PMID: 22877502
4
Examines SPOP regulation in bladder cancer progression, not ubiquitin C gene
PMID: 39479456
5
Studies cancer-associated fibroblasts in bladder cancer, not ubiquitin C gene
PMID: 36939397
6
Investigates NNMT in bladder cancer immunotherapy resistance, not ubiquitin C gene
PMID: 39067875
7
Reviews nectin-4 expression in genitourinary malignancies, not ubiquitin C gene
PMID: 39626158
8
Analyzes nectin-4 expression patterns in bladder cancer, not ubiquitin C gene
PMID: 39801278
Disease Associationsⓘ20
HIV infectionOpen Targets
0.57Moderate
listeriosisOpen Targets
0.53Moderate
cancerOpen Targets
0.52Moderate
dengue diseaseOpen Targets
0.47Moderate
cystic fibrosisOpen Targets
0.47Moderate
tuberculosisOpen Targets
0.47Moderate
bacterial diseaseOpen Targets
0.47Moderate
severe acute respiratory syndromeOpen Targets
0.46Moderate
COVID-19Open Targets
0.37Weak
neuroinflammatory disorderOpen Targets
0.22Weak
central nervous system infectionOpen Targets
0.20Weak
Myocardial IschemiaOpen Targets
0.18Weak
multinodular goiterOpen Targets
0.16Weak
Alzheimer diseaseOpen Targets
0.11Weak
infectionOpen Targets
0.10Suggestive
neoplasmOpen Targets
0.09Suggestive
type 2 diabetes mellitusOpen Targets
0.09Suggestive
prostate cancerOpen Targets
0.08Suggestive
esophageal squamous cell carcinomaOpen Targets
0.08Suggestive
rheumatoid arthritisOpen Targets
0.08Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
USP9XProtein interaction100%TRIP12Protein interaction100%UBA2Protein interaction100%WWP2Protein interaction100%HECW1Protein interaction100%ZNF629Protein interaction100%
Tissue Expression6 tissues
Lung
100%
Bone Marrow
69%
Heart
61%
Brain
50%
Liver
46%
Ovary
40%
Gene Interaction Network
Click a node to explore
UBCUSP9XTRIP12UBA2WWP2HECW1ZNF629
PROTEIN STRUCTURE
Preparing viewer…
PDB6Q00 · 0.85 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.49Moderately Constrained
pLIⓘ
0.99Intolerant
Observed/Expected LoF0.27 [0.16–0.49]
RankingsWhere UBC stands among ~20K protein-coding genes
  • #95of 20,598
    Most Researched1,371 · top 1%
  • #2,885of 17,882
    Most Constrained (LOEUF)0.49 · top quartile
Genes detectedUBC
Sources retrieved50 papers
Response time—
📄 Sources
50▼
1
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.
PMID: 20104584
Hum Mutat · 2010
1.00
2
Risk Factors Associated with Urothelial Bladder Cancer.
PMID: 39063530
Int J Environ Res Public Health · 2024
0.90
3
Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product.
PMID: 16368532
Front Biosci · 2006
0.84
4
Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
PMID: 1315303
Genomics · 1992
0.82
5
Epidemiology and risk factors of urothelial bladder cancer.
PMID: 22877502
Eur Urol · 2013
0.80