UBXN10 (UBX domain protein 10) is a VCP/p97-binding adapter protein with a primary role in ciliogenesis. It localizes to cilia in a VCP-dependent manner and acts as a tethering factor that recruits the AAA-ATPase VCP/p97 to the intraflagellar transport B (IFT-B) complex, which regulates anterograde transport into cilia 1. Both VCP and UBXN10 are required for proper ciliogenesis; UBXN10 depletion in zebrafish causes left-right asymmetry defects dependent on functional cilia 1. UBXN10 represents one of over 195 proteins in the VCP-UBXD adapter network, suggesting roles in diverse cellular pathways 1. Clinically, UBXN10 has emerged as a biomarker in multiple cancer contexts. It demonstrates predictive value for breast cancer survival and relapse-free survival 2, and was identified as a Grade-4 prostate cancer biomarker associated with aggressive disease 3. Additionally, its antisense transcript UBXN10-AS1 was identified as a down-regulated long non-coding RNA in prostate cancer [PMID:35414328; 4; 50] and colon adenocarcinoma, where it inhibits tumor progression via the miR-515-5p/SLIT3 axis 6. UBXN10 has also been identified as a plausible candidate gene for congenitally corrected transposition of the great arteries 7.