UGT2B11 is a UDP-glucuronosyltransferase enzyme involved in the conjugation and metabolism of steroid hormones and xenobiotics. The protein, consisting of 529 amino acids with 91% identity to UGT2B10, is highly expressed across multiple human tissues including liver, kidney, prostate, mammary gland, skin, adipose, adrenal, and lung tissues 1. While initial substrate screening detected no glucuronidation activity in transfected cells 1, subsequent studies demonstrated that UGT2B11 glucuronidates 3α-hydroxyandrogens and -pregnanes, though at lower rates compared to UGT2B7 2. The enzyme exhibits high stereo- and regioselectivity in steroid hormone metabolism. UGT2B11 is located within a complex cluster of UGT2B genes on chromosome 4 3. Beyond steroid metabolism, UGT2B11 participates in lipid metabolic reprogramming and xenobiotic detoxification pathways 45. Recent evidence suggests UGT2B11 plays a role in regulating lipid metabolism through PPARG signaling, particularly influencing longevity phenotypes in females 6. The enzyme may contribute to steroid hormone biosynthesis pathways implicated in prostate cancer progression 7.