URGCP (upregulator of cell proliferation) is a novel oncogene located on chromosome 7 that encodes a 922-amino acid cytoplasmic protein 1. Primary function: URGCP promotes cell cycle progression through stimulation of cyclin D1 (CCND1) mRNA expression 2, 3. Mechanism: In non-small cell lung cancer, URGCP activates NF-κB signaling to enhance MMP-9 expression, promoting invasion and metastasis 4. In glioma, URGCP represses miR-16 expression via NF-κB/c-myc pathway activation, leading to upregulation of Cyclin D1 and E1 5. Disease relevance: URGCP is significantly overexpressed across multiple cancer types including hepatocellular carcinoma, gastric cancer, osteosarcoma, neuroblastoma, and glioma 1. High URGCP expression correlates with poor prognosis and worse clinical outcomes in HCC and NSCLC 6, 4. Clinical significance: Downregulating URGCP suppresses cancer cell proliferation, invasion, and metastasis 4, 5, while therapeutic agents like retinoic acid and valproic acid reduce URGCP expression in neuroblastoma cells 7, 2. URGCP represents a potential therapeutic target and prognostic biomarker for multiple malignancies.