USHBP1 is a PDZ domain-binding protein located on chromosome 19 that functions as a component of the USH1 protein network. Structurally, USHBP1 interacts with PDZ domain-containing proteins, as evidenced by its binding to AIE-75 (harmonin), a PDZ-domain protein with three protein-protein interaction domains 1. This interaction suggests USHBP1 may function as part of a molecular anchoring or sorting complex. Clinically, USHBP1 has emerged as relevant in two disease contexts. First, it was identified as a stemness-related gene in hepatocellular carcinoma (HCC), where elevated USHBP1 expression correlates with poor prognosis; a five-gene survival model incorporating USHBP1 demonstrated high sensitivity and specificity for predicting HCC patient outcomes 2. Second, genetic variants in the USHBP1 region on chromosome 19.11 were associated with hippocampal volume variation in a genome-wide association study of schizophrenia, with allelic differences showing differential mRNA expression and associations with memory function 3. These findings suggest USHBP1 involvement in both neoplastic and neuropsychiatric pathogenesis, though the mechanistic basis remains unclear and warrants further investigation.