UXT (ubiquitously expressed prefoldin like chaperone) is a multifunctional protein that serves as both a molecular chaperone and transcriptional regulator with diverse cellular roles. As a chaperone, UXT functions as an autophagy adaptor that binds to protein aggregates and interacts with p62/SQSTM1 to promote aggrephagy, facilitating the clearance of misfolded proteins and preventing proteotoxicity 1. In transcriptional regulation, UXT forms complexes with other proteins like URI to act as a transcriptional repressor, particularly in prostate cells where it binds to androgen receptor and affects chrX structure 2. UXT also regulates Notch signaling by binding to promoters of Notch target genes and interfering with NICD-RBP-Jκ interactions, thereby promoting angiogenesis 3. In immune regulation, UXT associates with Foxp3 in regulatory T cells and is essential for their suppressive function 4. UXT plays protective roles in retinal health by suppressing autophagy through mTOR regulation, with knockout mice developing retinitis pigmentosa-like features 5. The protein also regulates epithelial cell differentiation by controlling ZONAB nuclear translocation 6. UXT expression is altered in various cancers, where it can function as either a tumor suppressor or oncogene depending on the cellular context 78.