VIPR2 (vasoactive intestinal peptide receptor 2) is a G protein-coupled receptor located on chromosome 7.3 that binds vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) with binding affinity order PACAP38 = VIP > PACAP27 1. Ligand binding triggers conformational changes activating cAMP-dependent signaling pathways and potentially phospholipase C 1. VIPR2 functions as a homodimer through transmembrane domains 3-4, which is essential for efficient VIP binding and Gαi protein interaction 2. An intramolecular disulfide bond between Cys25 and Cys192 is functionally significant for downstream AKT phosphorylation 3. Clinically, VIPR2 dysfunction associates with multiple disorders. Microduplications at 7q36.3 containing VIPR2 are linked to schizophrenia and possibly autism spectrum disorder, potentially through disrupted cortical circuit maturation during development 14. Loss of VIPR2 function causes myopia in humans and mice by impairing bipolar cell signaling 5. VIPR2 regulates circadian rhythms and metabolic homeostasis; the rs6950857 variant association with metabolic syndrome is modifiable by seaweed consumption 6. Additionally, VIPR2 is expressed on innate lymphoid cells and may regulate immune responses 7. VIPR2 represents a therapeutic target for cancer progression, neuropsychiatric disorders, refractive errors, and metabolic disease.