VPS36 encodes a core component of the ESCRT-II complex (endosomal sorting complex required for transport II) that functions in multivesicular body formation and protein sorting for lysosomal degradation 12. The protein directly interacts with other ESCRT-II components and mediates membrane recruitment through binding partners like RILP 1. VPS36 plays a critical role in regulating EGFR degradation by binding to and stabilizing the ESCRT-III association, affecting subsequent recruitment of deubiquitinating enzymes 2. Beyond endosomal sorting, VPS36 demonstrates cell-type-specific functions, particularly in lens development where it facilitates PI(3,4)P2-mediated cytokinetic abscission to prevent premature senescence and cataract formation 3. In disease contexts, VPS36 expression is frequently downregulated in advanced prostate cancer and correlates with poor patient outcomes 4. The protein also exhibits antiviral properties, as overexpression suppresses porcine epidemic diarrhea virus replication through interaction with viral ORF3 protein 5. Additionally, VPS36 has been identified as a candidate gene for novel human genetic diseases, suggesting broader clinical relevance 6.