VPS8 is a component of the CORVET (class C core vacuole/endosome tethering) complex, which functions as a Rab5 effector in early endosome fusion and the Rab5-to-Rab7 endosome conversion 1. VPS8 acts as a membrane tether that mediates SNARE complex assembly and endosomal vesicle fusion, predominantly localizing to APPL1-containing early endosomes 1. Beyond its canonical role in early endosome homotypic fusion, VPS8 regulates specialized vesicular transport from early to recycling endosomes, localizing to Rab4-positive recycling vesicles and Rab11-positive recycling endosomes 2. VPS8 depletion impairs integrin trafficking and plasma membrane delivery, causing defects in cell adhesion, spreading, and migration 2. The stoichiometric balance of VPS8 relative to HOPS-specific subunits (particularly VPS41) is critical; VPS8 overexpression competitively inhibits HOPS assembly and autophagosome-lysosome fusion 3 4. Structurally, VPS8 contains a RING domain with a disordered C-terminal segment required for CORVET integration 5. Clinically, VPS8 variants associate with Takayasu arteritis susceptibility 6 and are emerging candidate genes for late-onset Parkinson's disease with potential roles in signal transduction and endocytic recycling 7.