Based on limited published evidence, VWC2L (von Willebrand factor C domain containing 2 like) is a secreted cysteine knot protein that modulates bone and neural development. In osteoblasts, VWC2L accelerates matrix mineralization and increases Osterix expression, likely through TGF-β superfamily signaling 1. As a BMP antagonist of the Chordin family, VWC2L weakly inhibits BMP activity and promotes neurogenesis in neural precursor cells 2. The protein is expressed in brain tissue and ubiquitously across other tissues. VWC2L's functions align with its annotation for negative regulation of BMP signaling and involvement in neurogenesis and bone differentiation.