VXN (vexin), the human homolog of C8orf46, is a nuclear protein required for neurogenesis in the developing central nervous system and retina 1. As a target gene of neural basic helix-loop helix (bHLH) transcription factors, VXN cooperates with these proneural factors to promote neuronal differentiation and inhibit cell proliferation 1. The protein localizes to both the cell membrane and nucleus, with its neurogenic function operating through nuclear mechanisms that enhance expression of proneural proteins like Neurog2 and work synergistically with the cyclin-dependent kinase inhibitor p27Xic1 1. This function is conserved across vertebrate species, as demonstrated by studies in Xenopus and mouse models 1. Beyond its developmental role, VXN has emerged as a disease-relevant marker; it was identified as one of the most prominent protein components of granulovacuolar degeneration (GVD) bodies in Alzheimer's disease, a pathological feature associated with neurofibrillary tangles 2. These findings suggest VXN plays dual roles: promoting normal neurogenesis during development while potentially participating in neurodegenerative processes in Alzheimer's disease pathology.