WBP1L (WW domain binding protein 1 like) is a transmembrane adaptor protein that functions as a negative regulator of CXCR4 chemokine receptor signaling and plays important roles in hematopoiesis 1. The protein interacts with NEDD4-family ubiquitin ligases to regulate CXCR4 ubiquitination and expression, affecting multiple leukocyte subsets 1. WBP1L expression correlates with ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia, and serves as a direct transcriptional target of the ETV6 tumor suppressor 2. Genetic variants in WBP1L show significant associations with multiple diseases: rs4147157 is associated with schizophrenia risk and symptom severity in Chinese populations 3, blood pressure regulation 45, and age-related macular degeneration 6. The gene appears in conjoined gene transcripts (WBP1L-CNNM2) in B-cell lymphomas 7 and represents a robust prognostic biomarker in serous ovarian cancer 8. Analysis of Wbp1l-deficient mice reveals alterations in B cell development and enhanced bone marrow transplantation efficiency, confirming its regulatory role in hematopoietic processes 1.