WDR59 functions as a key component of the GATOR2 complex, a pentameric protein assembly that regulates mTORC1 signaling in response to amino acid availability 1. The GATOR2 complex, containing WDR24, MIOS, WDR59, SEH1L, and SEC13, adopts a large cage-like architecture where WDR59 contributes to the octagonal scaffold structure through α-solenoids and helps orient WD40 β-propeller domains that mediate interactions with nutrient sensors 2. WDR59 exhibits context-dependent functions in TORC1 regulation: in some tissues it promotes TORC1 activity by stabilizing GATOR2 components and preventing their proteolytic degradation, while in others it inhibits TORC1 by opposing GATOR2's inhibition of GATOR1 3. The protein is essential for GATOR2-mediated interactions with mTORC2, facilitating Sestrin2-induced AKT activation through the GATOR2-mTORC2 axis 4. WDR59 also plays a role in proper lysosomal localization of the GATOR complex, which is crucial for nutrient sensing 5. Beyond metabolic regulation, genetic variants in WDR59 have been associated with sleep-related traits, particularly snoring, suggesting broader physiological roles 6.